Luca Azzolin, Tito Panciera, Sandra Soligo, Elena Enzo, Silvio Bicciato, Sirio Dupont, Silvia Bresolin, Chiara Frasson, Giuseppe Basso, Vincenza Guzzardo, Ambrogio Fassina, Michelangelo Cordenonsi, Stefano Piccolo
The Hippo transducers YAP/TAZ have been shown to play positive, as well as negative, roles in Wnt signaling, but the underlying mechanisms remain unclear. Here, we provide biochemical, functional, and genetic evidence that YAP and TAZ are integral components of the β-catenin destruction complex that serves as cytoplasmic sink for YAP/TAZ. In Wnt-ON cells, YAP/TAZ are physically dislodged from the destruction complex, allowing their nuclear accumulation and activation of Wnt/YAP/TAZ-dependent biological effects...
July 3, 2014: Cell