journal
https://read.qxmd.com/read/38731257/assessing-the-preservation-of-lumbar-lordotic-curvature-in-everyday-sitting-conditions-assessed-with-an-inertial-measurement-system
#1
JOURNAL ARTICLE
Ju Chan Kim, Jeong-Gil Kim, Beom Suk Kim, Cheol Ki Kim, Minseok Choi, Joonnyong Lee, Sun Gun Chung
Background/Objectives: Lumbar lordotic curvature (LLC), closely associated with low back pain (LBP) when decreased, is infrequently assessed in clinical settings due to the spatiotemporal limitations of radiographic methods. To overcome these constraints, this study used an inertial measurement system to compare the magnitude and maintenance of LLC across various sitting conditions, categorized into three aspects: verbal instructions, chair type, and desk task types. Methods: Twenty-nine healthy participants were instructed to sit for 3 min with two wireless sensors placed on the 12th thoracic vertebra and the 2nd sacral vertebra...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731256/understanding-patterns-of-adherence-to-antifibrotic-treatment-in-idiopathic-pulmonary-fibrosis-insights-from-an-italian-prospective-cohort-study
#2
JOURNAL ARTICLE
Marica Iommi, Francesca Gonnelli, Martina Bonifazi, Andrea Faragalli, Federico Mei, Marco Pompili, Flavia Carle, Rosaria Gesuita
Background : Pirfenidone and Nintedanib have significantly improved the prognosis of patients with idiopathic pulmonary fibrosis (IPF), reducing mortality risk and exacerbations. This study aimed to analyze antifibrotic treatment utilization and its association with clinical outcomes (i.e., acute exacerbation or death) during 2014-2021 in newly diagnosed IPF patients, using Healthcare Utilization Databases of the Marche Region, Italy. Methods : The first 12-month adherence to antifibrotic was estimated using the Proportion of Days Covered (PDC), defining adherence as PDC ≥ 75%...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731255/secondary-microsurgical-reconstruction-of-the-cervical-esophagus-safer-flaps-and-practical-tips-in-a-challenging-situation
#3
JOURNAL ARTICLE
Vittorio Ramella, Andrea Ferrari, Federico Cesare Novati, Zoran Marij Arnež, Grace Marchi, Agostino Rodda, Stefano Bottosso, Giovanni Papa
Background : Cervical esophageal reconstruction is vital to improve the quality of life in cancer surgery patients. Microsurgery is crucial in providing vascularized tissue for defect repair, particularly in secondary cases with a higher risk of failure due to larger defects and damage from previous surgery and radiotherapy. The purpose of this study was to describe the clinical characteristics of a series of patients who underwent secondary repair of esophageal defects and provide practical information for the management and treatment of such cases based on the authors' experience and the literature review...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731254/neural-adaptation-at-stimulus-onset-and-speed-of-neural-processing-as-critical-contributors-to-speech-comprehension-independent-of-hearing-threshold-or-age
#4
JOURNAL ARTICLE
Jakob Schirmer, Stephan Wolpert, Konrad Dapper, Moritz Rühle, Jakob Wertz, Marjoleen Wouters, Therese Eldh, Katharina Bader, Wibke Singer, Etienne Gaudrain, Deniz Başkent, Sarah Verhulst, Christoph Braun, Lukas Rüttiger, Matthias H J Munk, Ernst Dalhoff, Marlies Knipper
Background : It is assumed that speech comprehension deficits in background noise are caused by age-related or acquired hearing loss. Methods : We examined young, middle-aged, and older individuals with and without hearing threshold loss using pure-tone (PT) audiometry, short-pulsed distortion-product otoacoustic emissions (pDPOAEs), auditory brainstem responses (ABRs), auditory steady-state responses (ASSRs), speech comprehension (OLSA), and syllable discrimination in quiet and noise. Results : A noticeable decline of hearing sensitivity in extended high-frequency regions and its influence on low-frequency-induced ABRs was striking...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731253/clinical-efficacy-of-application-linked-stretching-ball-as-digital-therapeutics-in-plantar-fasciitis
#5
JOURNAL ARTICLE
Seok Chang Ryu, Dong-Oh Lee, Yoojin Park, Yujeong Shin, Dong Yeon Lee, Min Gyu Kyung
Background/Objectives : This study aimed to evaluate the efficacy of application-linked stretching ball instruments that record the rolling time and force of patients compared with a traditional simple stretching ball. Methods : Fourteen participants with plantar fasciitis were divided into a simple massage ball group (group A, n = 8) and an application-linked massage ball group (group B, n = 6). The application-linked massage ball sends information regarding the massages, such as the frequency and force of the massage on the foot, to the application on the patient's smartphone...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731252/the-effect-of-physical-activity-and-repeated-whole-body-cryotherapy-on-the-expression-of-modulators-of-the-inflammatory-response-in-mononuclear-blood-cells-among-young-men
#6
JOURNAL ARTICLE
Justyna Kusmierczyk, Magdalena Wiecek, Gabriela Wojciak, Mateusz Mardyła, Grzegorz Kreiner, Zbigniew Szygula, Jadwiga Szymura
Background: Series of whole-body cryotherapy (WBC) among healthy and physically active individuals can potentially reduce inflammatory response, although exact mechanisms remain unclear. Methods: The impact of whole-body cryotherapy on inflammation modulators among 28 young males, categorized as non-training (NTR, N = 10), non-training with WBC (NTR-WBC, N = 10), and training with WBC (TR-WBC, N = 8), is investigated in this study. Over a period of eight weeks, NTR-WBC and TR-WBC subjects underwent 24 WBC treatments (-130 °C for 3 min, three times a week), examining changes in mRNA expressions of IL-1A, IL-6, IL-10, IFN-G, SIRT1, SIRT3, SOD2, GSS, and ICAM-1...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731251/alcohol-consumption-is-a-coping-mechanism-for-male-patients-with-severe-anxiety-disorders-treated-with-antidepressants-monotherapy
#7
JOURNAL ARTICLE
Mădălina Iuliana Mușat, Felicia Militaru, Ion Udriștoiu, Smaranda Ioana Mitran, Bogdan Cătălin
Background: Anxiety disorders are prevalent mental health conditions often accompanied by various comorbidities. The association between anxiety and liver disease, as well as fluctuations in blood sugar levels, highlights the importance of carefully evaluating patients with anxiety undergoing antidepressant therapy. The aim of this study was to conduct a comparative assessment of liver function and blood glucose levels in patients diagnosed with anxiety disorders while considering potential gender-specific differences...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731250/prospective-analysis-of-squamous-cell-carcinoma-antigen-1-and-2-for-diagnosing-sinonasal-inverted-papilloma
#8
JOURNAL ARTICLE
Hitoshi Hirakawa, Taro Ikegami, Masatomo Toyama, Yurika Ooshiro, Tomoyo Higa, Hidetoshi Kinjyo, Shunsuke Kondo, Norimoto Kise, Yukashi Yamashita, Mikio Suzuki
Background : The goal of this research was to confirm whether preoperative serum squamous cell carcinoma antigen (SCCA)-1 and -2 levels are useful diagnostic markers for sinonasal inverted papilloma (IP) in a prospective study. Methods : Participants were 102 patients who underwent consecutive endoscopic sinus surgery: 18 with IP, two with other types of papilloma, 77 with chronic rhinosinusitis, four with sinonasal cancer, and one with hemangioma. SCCA-1 and SCCA-2 were measured preoperatively by an automatic chemiluminescence immunoassay and an enzyme-linked immunosorbent assay, respectively...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731249/the-multidisciplinary-mobile-unit-mmu-program-bringing-hospital-specialist-geriatric-competencies-at-home-a-feasible-alternative-to-admission-in-older-patients-with-urgent-complaints
#9
JOURNAL ARTICLE
Antonio Nouvenne, Andrea Ticinesi, Carmine Siniscalchi, Martina Rendo, Nicoletta Cerundolo, Alberto Parise, Giampiero Castaldo, Giulia Chiussi, Richard Carrassi, Angela Guerra, Tiziana Meschi
Background/Objectives : Older patients are subject to a high number of Emergency Department (ED) visits and hospitalizations. Innovative strategies to manage geriatric urgencies in the community are thus needed. Methods : In this prospective observational study, we examined the case mix of a hospital-based domiciliary urgent care service tailored to older patients, called Multidisciplinary Mobile Unit (MMU), from January to September 2023. The service, activated by general practitioners or territorial specialists during workdays, provided domiciliary geriatric assessment, point-of-care diagnostics, including multi-site ultrasound and lab tests, and therapeutical measures, including intravenous treatment and insertion of invasive devices, with the goal of reaching on-site stabilization and avoiding ED referral...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731248/role-of-vascular-function-in-the-prognosis-of-heart-failure-patients
#10
JOURNAL ARTICLE
Shunsuke Kiuchi, Shinji Hisatake, Shintaro Dobashi, Yoshiki Murakami, Takanori Ikeda
Background: Blood vessels have the Windkessel effect and are involved in blood circulation. The breakdown of this mechanism is also involved in the pathogenesis of heart failure (HF); however, the relationship between vascular dysfunction and HF prognosis is not fully understood. Methods : We evaluated 214 patients hospitalized for HF at our institution who underwent a cardio-ankle vascular index (CAVI), which evaluates vascular function, between January 2012 and July 2018. To investigate factors (including CAVI) associated with major adverse cardiac events (MACE) during 1 year after patients with HF were discharged, we evaluated clinical profiles, blood tests, chest X-P, 12-lead electrocardiography, and transthoracic echocardiographic findings...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731247/creation-and-validation-of-patient-derived-cancer-model-using-peritoneal-and-pleural-effusion-in-patients-with-advanced-ovarian-cancer-an-early-experience
#11
JOURNAL ARTICLE
Ruri Nishie, Tomohito Tanaka, Kensuke Hirosuna, Shunsuke Miyamoto, Hikaru Murakami, Hiromitsu Tsuchihashi, Akihiko Toji, Shoko Ueda, Natsuko Morita, Sousuke Hashida, Atsushi Daimon, Shinichi Terada, Hiroshi Maruoka, Hiromi Konishi, Yuhei Kogata, Kohei Taniguchi, Kazumasa Komura, Masahide Ohmichi
Background : The application of personalized cancer treatment based on genetic information and surgical samples has begun in the field of cancer medicine. However, a biopsy may be painful for patients with advanced diseases that do not qualify for surgical resection. Patient-derived xenografts (PDXs) are cancer models in which patient samples are transplanted into immunodeficient mice. PDXs are expected to be useful for personalized medicine. The aim of this study was to establish a PDX from body fluid (PDX-BF), such as peritoneal and pleural effusion samples, to provide personalized medicine without surgery...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731246/cardiopulmonary-resuscitation-clinical-updates-and-perspectives
#12
EDITORIAL
Stephan Marsch, Timur Sellmann
Cardiopulmonary resuscitation (CPR) stands as a cornerstone in emergency care, representing the crucial link between life and death for victims of cardiac arrest [...].
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731245/endovascular-recanalization-and-carotid-stenting-the-new-approach-to-restore-cerebral-perfusion-during-aortic-dissection
#13
JOURNAL ARTICLE
Maxim Agarkov, Kirill Kozlov, Ekaterina Senkina, Sergey Gornov, Natalia Linkova, Elena Kechaeva, Dmitrii Medvedev, Alexander Krasichkov, Anastasiia Dyatlova, Victoria Polyakova
UNLABELLED: A type A aortic dissection (TAAD) is a dangerous condition requiring emergency surgery. Due to the similarity of the symptoms of cerebral malperfusion in TAAD and the signs of ischemic stroke, a differential diagnosis of these diseases is not always available. Patients with TAAD after cerebral malperfusion can have a neurological deficit. Thrombolysis is performed in this case. It can worsen the patient's condition and increase the risk of mortality and disability. The aim of the study is to evaluate the new approach to restoring cerebral perfusion during aortic dissection...
May 6, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731244/revolutionizing-localized-lung-cancer-treatment-neoadjuvant-chemotherapy-plus-immunotherapy-for-all
#14
REVIEW
Victoria Ferrari, Carole Helissey
Lung cancer poses a significant public health challenge, with resectable non-small cell lung cancer (NSCLC) representing 20 to 25% of all NSCLC cases, staged between I and IIIA. Despite surgical interventions, patient survival remains unsatisfactory, with approximately 50% mortality within 5 years across early stages. While perioperative chemotherapy offers some benefit, outcomes vary. Therefore, novel therapeutic approaches are imperative to improve patient survival. The combination of chemotherapy and immunotherapy emerges as a promising avenue...
May 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731243/dyslipidemia-cholangitis-and-fatty-liver-disease-the-close-underexplored-relationship-a-narrative-review
#15
REVIEW
Salvatore Greco, Michele Campigotto, Andrea D'Amuri, Nicolò Fabbri, Angelina Passaro
In assessing individual cardiovascular risk, dyslipidemia is known for emerging as a pivotal factor significantly contributing to major cardiovascular events. However, dyslipidemic patients frequently present with concurrent medical conditions, each with varying frequencies of occurrence; cholangitis, whether acute or chronic, and hepatic steatosis, along with associated conditions, are strongly associated with specific forms of dyslipidemia, and these associations are reasonably well elucidated. Conversely, evidence linking biliary disease to hepatic steatosis is comparatively scant...
May 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731242/combined-endoscopic-endonasal-transclival-and-contralateral-transmaxillary-approach-to-the-petrous-apex-and-the-petroclival-synchondrosis-working-around-the-corner-of-the-internal-carotid-artery-quantitative-anatomical-study-and-clinical-applications
#16
JOURNAL ARTICLE
Carmine Antonio Donofrio, Francesco Corrivetti, Lucia Riccio, Sergio Corvino, Iacopo Dallan, Antonio Fioravanti, Matteo de Notaris
The endoscopic contralateral transmaxillary (CTM) approach has been proposed as a potential route to widen the corridor posterolateral to the internal carotid artery (ICA). In this study, we first refined the surgical technique of a combined multiportal endoscopic endonasal transclival (EETC) and CTM approach to the petrous apex (PA) and petroclival synchondrosis (PCS) in the dissection laboratory, and then validated its applications in a preliminary surgical series. The combined EETC and CTM approach was performed on three cadaver specimens based on four surgical steps: (1) the nasal, (2) the clival, (3) the maxillary and (4) the petrosal phases...
May 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731241/chordoma-genetic-aberrations-and-targeted-therapies-panorama-a-systematic-literature-review
#17
REVIEW
Edoardo Agosti, Sara Antonietti, Marco Zeppieri, Tamara Ius, Alessandro Fiorindi, Alessandro Tel, Massimo Robiony, Pier Paolo Panciani, Marco Maria Fontanella
Background : Chordomas pose a challenge in treatment due to their local invasiveness, high recurrence, and potential lethality. Despite being slow-growing and rarely metastasizing, these tumors often resist conventional chemotherapies (CTs) and radiotherapies (RTs), making surgical resection a crucial intervention. However, achieving radical resection for chordomas is seldom possible, presenting therapeutic challenges. The accurate diagnosis of these tumors is vital for their distinct prognoses, yet differentiation is hindered by overlapping radiological and histopathological features...
May 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731240/the-transorbital-approach-a-comprehensive-review-of-targets-surgical-techniques-and-multiportal-variants
#18
REVIEW
Matteo De Simone, Cesare Zoia, Anis Choucha, Doo-Sik Kong, Lucio De Maria
The transorbital approach (TOA) is gaining popularity in skull base surgery scenarios. This approach represents a valuable surgical corridor to access various compartments and safely address several intracranial pathologies, both intradurally and extradurally, including tumors of the olfactory groove in the anterior cranial fossa (ACF), cavernous sinus in the middle cranial fossa (MCF), and the cerebellopontine angle in the posterior cranial fossa (PCF). The TOA exists in many variants, both from the point of view of invasiveness and from that of the entry point to the orbit, corresponding to the four orbital quadrants: the superior eyelid crease (SLC), the precaruncular (PC), the lateral retrocanthal (LRC), and the preseptal lower eyelid (PS)...
May 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731239/analysis-of-safety-and-efficacy-of-the-early-initiation-of-antithrombotic-secondary-prevention-in-patients-treated-with-intravenous-thrombolysis-for-acute-ischemic-stroke
#19
JOURNAL ARTICLE
Georgi Krastev, Miroslav Mako, Zuzana Števková, Romana Havranová, Kristína Andrášiková
Background and Objectives : Current guidelines and the alteplase product insert recommend that antithrombotic therapy be avoided within 24 h of intravenous thrombolytic therapy with rt-PA in acute ischemic stroke. Therefore, the rate of stroke recurrence is unclear in terms of early neurological deterioration, which we could prevent with the early administration of antithrombotic therapy. We do not know the effect of early antithrombotic therapy after intravenous thrombolysis with rt-PA in acute stroke on the outcome in patients after 90 days either...
May 5, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38731238/challenges-in-echocardiography-for-the-diagnosis-and-prognosis-of-non-ischemic-hypertensive-heart-disease
#20
REVIEW
Nikolaos P E Kadoglou, Angeliki Mouzarou, Nikoleta Hadjigeorgiou, Ioannis Korakianitis, Michael M Myrianthefs
It has been well established that arterial hypertension is considered as a predominant risk factor for the development of cardiovascular diseases. Despite the link between arterial hypertension and cardiovascular diseases, arterial hypertension may directly affect cardiac function, leading to heart failure, mostly with preserved ejection fraction (HFpEF). There are echocardiographic findings indicating hypertensive heart disease (HHD), defined as altered cardiac morphology (left ventricular concentric hypertrophy, left atrium dilatation) and function (systolic or diastolic dysfunction) in patients with persistent arterial hypertension irrespective of the cardiac pathologies to which it contributes, such as coronary artery disease and kidney function impairment...
May 4, 2024: Journal of Clinical Medicine
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